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Somatosensory temporal discrimination tested in patients receiving botulinum toxin injection for cervical dystonia
Author(s) -
Scontrini Alessandra,
Conte Antonella,
Fabbrini Giovanni,
Colosimo Carlo,
Di Stasio Flavio,
Ferrazzano Gina,
Berardelli Alfredo
Publication year - 2011
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23447
Subject(s) - cervical dystonia , botulinum toxin , dystonia , somatosensory system , medicine , neurological disorder , anesthesia , sensory system , focal dystonia , central nervous system disease , clostridium botulinum , neuroscience , toxin , psychology , biology , psychiatry , biochemistry
We designed this study to find out more about the relationship between the sensory effects of Botulinum toxin type A (BTX) and the clinical benefits of BTX therapy in patients with cervical dystonia (CD). In 24 patients with CD, we tested sensory temporal discrimination (STD) in the affected and two unaffected body regions (neck, hand, and eye) before and 1 month after BTX injection. In 8 out of the 24 patients with CD, STDT values were tested bilaterally in the three body regions before, 1 and 2 months after BTX injection. As expected, STD testing disclosed altered STD threshold values in all three body regions tested (affected and unaffected by dystonic spasms) in patients with CD. STD threshold values remained unchanged at all time points of the follow‐up in all CD patients. The lack of BTX‐induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation. © 2010 Movement Disorder Society