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Progressive parkinsonism, oculomotor abnormalities and autonomic dysfunction: Clinicopathological case
Author(s) -
Fabbrini Giovanni,
Merello Marcello,
Evans Andrew H.,
Lees Andrew J.,
Holton Janice,
Williams David R.
Publication year - 2011
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23302
Subject(s) - parkinsonism , pathological , levodopa , postural instability , medicine , eye movement , physical medicine and rehabilitation , psychology , pediatrics , parkinson's disease , neuroscience , pathology , disease
A 59‐year‐old woman presented with asymmetric parkinsonism that was not‐responsive to Levodopa therapy. She developed early falls, postural instability, and moderately severe autonomic dysfunction. Eye movement abnormalities were reported 2 years after her first symptoms, and she eventually developed anterocollis. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered. © 2011 Movement Disorder Society