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Staging of α‐synuclein in the olfactory bulb in a model of Parkinson's disease: Cell types involved
Author(s) -
UbedaBañon Isabel,
SaizSanchez Daniel,
de la RosaPrieto Carlos,
MohedanoMoriano Alicia,
Fradejas Noelia,
Calvo Soledad,
ArgandoñaPalacios Lucia,
GarciaMuñozguren Susana,
MartinezMarcos Alino
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23197
Subject(s) - olfactory bulb , substantia nigra , neuroscience , parkinson's disease , neuropathology , biology , olfaction , anterior olfactory nucleus , alpha synuclein , disease , pathology , medicine , olfactory tubercle , central nervous system
Impaired olfaction is an early symptom of Parkinson's disease. The underlying neuropathology likely includes α‐synucleinopathy in the olfactory bulb at an earlier stage (Braak's stage1) than pathology in the substantia nigra, which is not observed until stage 3. In this report, we investigated the distribution and cell types affected by α‐synuclein in the olfactory bulb of transgenic mice (2–8 months of age) expressing the human A53T variant of α‐synuclein. α‐Synuclein immunostaining progressively affects interneurons and mitral cells. Double labeling studies demonstrate that dopaminergic cells are hardly involved, whereas glutamatergic‐ and calcium binding protein‐positive cells are severely affected. This temporal evolution and the cell types expressing α‐synuclein are reminiscent of idiopathic Parkinson's disease and support the usefulness of this model to address specific topics in the premotor phase of the disease. © 2010 Movement Disorder Society