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Juvenile levodopa‐responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment
Author(s) -
Espay Alberto J.,
Paviour Dominic C.,
O'Sullivan John D.,
Schmidt Robert E.,
Revilla Fredy J.,
Metman Leo Verhagen
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.23194
Subject(s) - parkinsonism , levodopa , deep brain stimulation , psychology , physical medicine and rehabilitation , movement disorders , dopaminergic , eye movement , pathological , neuroscience , cognition , saccadic masking , resting tremor , cognitive impairment , medicine , parkinson's disease , audiology , disease , dopamine , pathology
A 13‐year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug‐induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered. © 2010 Movement Disorder Society