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Incidental Lewy body disease: Clinical comparison to a control cohort
Author(s) -
Adler Charles H.,
Connor Donald J.,
Hentz Joseph G.,
Sabbagh Marwan N.,
Caviness John N.,
Shill Holly A.,
Noble Brie,
Beach Thomas G.
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22971
Subject(s) - lewy body , dementia , cohort , medicine , dementia with lewy bodies , lewy body disease , cognitive test , disease , movement disorders , central nervous system disease , cohort study , degenerative disease , cognition , pediatrics , psychology , psychiatry , pathology
Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson's disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age‐similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences. © 2010 Movement Disorder Society