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Cognitive and functional decline in Huntington's disease: Dementia criteria revisited
Author(s) -
Peavy Guerry M.,
Jacobson Mark W.,
Goldstein Jody L.,
Hamilton Joanne M.,
Kane Amy,
Gamst Anthony C.,
Lessig Stephanie L.,
Lee J. C.,
CoreyBloom Jody
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22953
Subject(s) - dementia , huntington's disease , psychology , neuropathology , neuropsychology , context (archaeology) , clinical dementia rating , cognition , memory impairment , executive dysfunction , alzheimer's disease , disease , psychiatry , clinical psychology , medicine , cognitive impairment , paleontology , biology
The importance of designating criteria for diagnosing dementia lies in its implications for clinical treatment, research, caregiving, and decision‐making. Dementia diagnosis in Huntington's disease (HD) is often based on criteria developed for Alzheimer's disease requiring memory loss. However, it is likely that other cognitive deficits contribute to functional impairment in HD before memory declines. The goal is to identify cognitive deficits that contribute to functional impairment to support dementia criteria that reflect HD neuropathology. Eighty‐four HD mutation‐positive subjects completed neuropsychological tests and the Unified Huntington's Disease Rating Scale Functional Independence Scale (FIS). Functional impairment was defined as 80 or below on the FIS. Speed of processing, initiation, and attention measures accounted for 70.0% of the variance in FIS ratings (linear regression) and correctly classified 91.7% of subjects as functionally impaired or intact (logistic regression). Measures of memory, motor impairment except dysarthria, neuroleptic use, and depressed mood did not improve prediction. A definition of HD dementia that includes cognitive impairment in at least two areas of cognition but does not require a memory deficit, in the context of impaired functional abilities and a deteriorating course, more accurately reflects HD neuropathology and could lead to improved research methods and patient care. © 2010 Movement Disorder Society