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Differential pattern of brain‐specific CSF proteins tau and amyloid‐beta in Parkinsonian syndromes
Author(s) -
Süssmuth Sigurd D.,
Uttner Ingo,
Landwehrmeyer Bernhard,
Pinkhardt Elmar H.,
Brettschneider Johannes,
Petzold Axel,
Kramer Bernd,
Schulz Jörg B.,
Palm Christian,
Otto Markus,
Ludolph Albert C.,
Kassubek Jan,
Tumani Hayrettin
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22895
Subject(s) - progressive supranuclear palsy , parkinsonism , cerebrospinal fluid , glial fibrillary acidic protein , neurodegeneration , tau protein , atrophy , pathology , medicine , alzheimer's disease , degenerative disease , biomarker , endocrinology , psychology , central nervous system disease , biology , disease , immunohistochemistry , biochemistry
To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP‐Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid‐beta 1–42 (Aβ1–42), Aβ1–40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP‐Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age‐matched controls ( P ≤ 0.001). Ratios of P‐tau/T‐tau were significantly different in Parkinsonian syndromes. CSF Aβ1–42 was decreased only in patients with Richardson's syndrome. In a subset of Parkinsonian syndromes, we found elevated GFAP concentrations and increased CSF/serum albumin ratios. There were no correlations between biomarker concentrations and clinical scores in any of the diseases. In conclusion, this preliminary data show that changes in CSF tau and Aβ1–42 may indicate different protein processing in PSP patients and might, therefore, be relevant in the differentiation of PSP subtypes. © 2010 Movement Disorder Society