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LINGO1 polymorphisms are associated with essential tremor in Europeans
Author(s) -
Thier Sandra,
Lorenz Delia,
Nothnagel Michael,
Stevanin Giovanni,
Dürr Alexandra,
Nebel Almut,
Schreiber Stefan,
Kuhlenbäumer Gregor,
Deuschl Günther,
Klebe Stephan
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22887
Subject(s) - genetics , biology , candidate gene , gene , essential tremor , genetic association , phenotype , odds ratio , genotype , genome wide association study , single nucleotide polymorphism , bioinformatics , medicine , neuroscience
Essential tremor (ET) is one of the most common movement disorders. Former association studies focussing on candidate genes in ET found a number of risk variants but most of them were not replicated. Recently, a genome‐wide association study revealed two intronic sequence variants in the LINGO1 gene associated with ET. Here, we have confirmed association between sequence variants in the LINGO1 gene and the ET phenotype in independent German and French ET samples. The odds ratios for the identified intronic markers rs8030859 ( P = 1.0×10 −4 ), rs9652490 ( P = 9.1×10 −4 ), and rs11856808 ( P = 3.6×10 −2 ) were 1.72 (CI 1.31‐2.26), 1.61 (CI 1.21‐2.14), and 1.30 (CI 1.02‐1.66), respectively, in our German sample. LINGO1 is an interesting candidate gene because it plays a key role in central nervous system biology, is selectively expressed in the nervous system, and is an inhibitor of oligodendrocyte differentiation and neuronal myelination. Our study gives further evidence that LINGO1 acts as a susceptibility gene for ET. © 2010 Movement Disorder Society