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The role of parkin in familial and sporadic Parkinson's disease
Author(s) -
Dawson Ted M.,
Dawson Valina L.
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22798
Subject(s) - parkin , ubiquitin ligase , parkinson's disease , pathogenesis , ubiquitin , genetics , disease , biology , ubiquitin protein ligases , mutation , neuroscience , bioinformatics , medicine , immunology , gene , pathology
Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. © 2010 Movement Disorder Society
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