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Alpha‐synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population
Author(s) -
Rajput Alex,
VilariñoGüell Carles,
Rajput Michele L.,
Ross Owen A.,
SotoOrtolaza Alexandra I.,
Lincoln Sarah J.,
Cobb Stephanie A.,
Heckman Michael G.,
Farrer Matthew J.,
Rajput Ali
Publication year - 2009
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22795
Subject(s) - parkinsonism , parkinson's disease , age of onset , degenerative disease , disease , alpha synuclein , odds ratio , essential tremor , allele , lrrk2 , population , medicine , genetics , biology , gene , psychiatry , environmental health
Alpha‐synuclein gene ( SNCA ) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. We report a study of SNCA genetic variation in 452 idiopathic PD cases and 245 controls. SNCA copy number mutations were not associated with early‐onset disease in this population. The minor allele “G” at rs356165 was associated with increased odds of PD ( P = 0.013) and genetic variation in D4S3481 (Rep1) was associated with age of disease onset ( P = 0.007). There was a trend toward association between variation at rs2583988 and rapid PD progression. © 2009 Movement Disorder Society