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Role of serotonin neurons in the induction of levodopa‐ and graft‐induced dyskinesias in Parkinson's disease
Author(s) -
Carta Manolo,
Carlsson Thomas,
Muñoz Ana,
Kirik Deniz,
Björklund Anders
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22792
Subject(s) - levodopa , dopamine , serotonin , parkinson's disease , striatum , neuroscience , midbrain , medicine , dyskinesia , neurotransmitter , psychology , central nervous system , disease , receptor
Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory feedback control, dopamine released from serotonin terminals results in excessive swings in extracellular dopamine levels after peripheral administration of levodopa. Such “dysregulated” release of levodopa‐derived dopamine is likely to be responsible for the appearance of the abnormal movements in levodopa‐primed animals. This mechanism may also play a role in the development of graft‐induced dyskinesias in patients that receive fetal neuron transplants, possibly due to the inclusion of serotonin neurons in the grafted ventral midbrain tissue, which contribute to maintain dopamine receptors of the denervated striatum in a supersensitive state. © 2010 Movement Disorder Society