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Enhancing neuroplasticity in the basal ganglia: The role of exercise in Parkinson's disease
Author(s) -
Petzinger Giselle M.,
Fisher Beth E.,
Van Leeuwen JonEric,
Vukovic Marta,
Akopian Garnik,
Meshul Charlie K.,
Holschneider Daniel P.,
Nacca Angelo,
Walsh John P.,
Jakowec Michael W.
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22782
Subject(s) - parkinson's disease , neuroscience , basal ganglia , glutamatergic , dopaminergic , neuroplasticity , disease , degenerative disease , psychology , medicine , dopamine , central nervous system disease , central nervous system , glutamate receptor , receptor
Epidemiological and clinical trials have suggested that exercise is beneficial for patients with Parkinson's disease (PD). However, the underlying mechanisms and potential for disease modification are currently unknown. This review presents current findings from our laboratories in patients with PD and animal models. The data indicate that alterations in both dopaminergic and glutamatergic neurotransmission, induced by activity‐dependent (exercise) processes, may mitigate the cortically driven hyper‐excitability in the basal ganglia normally observed in the parkinsonian state. These insights have potential to identify novel therapeutic treatments capable of reversing or delaying disease progression in PD. © 2010 Movement Disorder Society