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Protein degradation, aggregation, and misfolding
Author(s) -
Cuervo Ana Maria,
Wong Esther S.P.,
MartinezVicente Marta
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22718
Subject(s) - neurodegeneration , neuroscience , intracellular , pathogenesis , parkinson's disease , disease , protein aggregation , biology , medicine , microbiology and biotechnology , immunology , pathology
The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease. © 2010 Movement Disorder Society