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Hyposmia in progressive supranuclear palsy
Author(s) -
SilveiraMoriyama Laura,
Hughes Graham,
Church Alistair,
Ayling Hilary,
Williams David R.,
Petrie Aviva,
Holton Janice,
Revesz Tamas,
Kingsbury Ann,
Morris Huw R.,
Burn David J.,
Lees Andrew J.
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22688
Subject(s) - progressive supranuclear palsy , hyposmia , parkinson's disease , degenerative disease , psychology , central nervous system disease , rem sleep behavior disorder , medicine , audiology , disease , pathology , gastroenterology , covid-19 , infectious disease (medical specialty)
Previous studies suggested that olfaction is normal in progressive supranuclear palsy (PSP). We applied the University of Pennsylvania Smell Identification Test (UPSIT) to 36 patients with PSP who scored more than 18 on the Mini Mental State Examination (MMSE), 140 patients with nondemented Parkinson's disease (PD) and 126 controls. Mean UPSIT scores in PSP were lower than in controls ( P < 0.001) but higher than in PD ( P < 0.001) after adjusting for age, gender, and smoking history. For patients with PSP, UPSIT scores correlated with MMSE ( r = 0.44, P = 0.006) but not disease duration ( P = 0.6), motor subscale of the Unified Parkinson's Disease Rating Scale ( P = 0.2), or Frontal Assessment Battery ( P = 0.5). The brains of six of the patients with PSP were examined postmortem and all revealed neurofibrillary tangles and tau accumulation in the rhinencephalon, although only three had hyposmia. Further prospective studies including patients with early PSP and PSP‐P with postmortem confirmation might help clarify if smell tests could be useful when the differential diagnosis lies between PD and PSP. © 2010 Movement Disorder Society