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Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration—[ 18 F]FDG‐PET
Author(s) -
Liepelt Inga,
Reimold Matthias,
Maetzler Walter,
Godau Jana,
Reischl Gerald,
Gaenslen Alexandra,
Herbst Heinz,
Berg Daniela
Publication year - 2009
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22662
Subject(s) - positron emission tomography , parkinson's disease , dementia , cognitive decline , disease , rating scale , medicine , psychology , cognition , degenerative disease , cardiology , nuclear medicine , neuroscience , developmental psychology
In Parkinson's disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [ 18 F]fluorodeoxyglucose‐positron emission tomography (FDG‐PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinson's disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty‐two Parkinson's patients (10 demented) and seven controls underwent FDG‐PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Minimental State Examination (MMSE)], motor performance [Unified Parkinson's Disease Rating Scale (UPDRS III)” and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE ( P < 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM‐IV diagnosis of dementia were high for the metabolic index (MI), with 91 and 100%. Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment. © 2009 Movement Disorder Society