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Comparison of three clinical rating scales in Friedreich ataxia (FRDA)
Author(s) -
Bürk Katrin,
Mälzig Ulrike,
Wolf Stefanie,
Heck Suzette,
Dimitriadis Konstantinos,
SchmitzHübsch Tanja,
Hering Sascha,
Lindig Tobias M.,
Haug Verena,
Timmann Dagmar,
Degen Ingrid,
Kruse Bernd,
Dörr JanMarkus,
Ratzka Susanne,
Ivo Anja,
Schöls Ludger,
Boesch Sylvia,
Klockgether Thomas,
Klopstock Thomas,
Schulz Jörg B.
Publication year - 2009
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22660
Subject(s) - ataxia , rating scale , inter rater reliability , psychology , physical therapy , physical medicine and rehabilitation , reliability (semiconductor) , medicine , psychiatry , developmental psychology , power (physics) , physics , quantum mechanics
To test the validity and reliability of the scale for the assessment and rating of ataxia (SARA) in Friedreich ataxia (FRDA). SARA is limited to eight items and can be performed rapidly. Ninety‐six patients with a molecular genetic diagnosis of FRDA were rated using three different clinical scales, the FRDA Rating Scale (FARS), the International Cooperative Ataxia Rating Scale (ICARS), and SARA. Despite considerable discrepancies in scale size and subscale structure, SARA total scores were significantly correlated with ICARS (r = 0.953, P < 0.0001) and FARS (r = 0.938, P < 0.0001) total scores. SARA total scores also correlated with the activities of daily living (ADL, r = 0.929, P < 0.0001). Although originally developed for the use in dominantly inherited ataxias, which are primarily ataxias of the cerebellar type, SARA can also be used successfully to assess afferent ataxia, which is the predominant form in FRDA. Because SARA is characterized by high interrater reliability and practicability, SARA is applicable and well suited forclinical trials of FRDA. © 2009 Movement Disorder Society