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Inflammation and Parkinson's disease pathogenesis
Author(s) -
Przedborski Serge
Publication year - 2010
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22638
Subject(s) - neuroprotection , inflammation , parkinson's disease , disease , pathogenesis , neuroscience , degenerative disease , medicine , immunology , psychology , pathology
Inflammation is a neuropathological feature of parkinsonian brains and also in experimental models of the disease. It is believed that activated glial cells, which compose the majority of this inflammatory response contribute to the neurodegenerative process through the production of toxic molecules. Therapeutic strategies geared toward reducing inflammation and inhibiting the production of these glial‐derived toxic molecules may be a promising neuroprotective strategy for the treatment of Parkinson's disease and related conditions. © 2010 Movement Disorder Society