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Metabolic networks for assessment of therapy and diagnosis in Parkinson's disease
Author(s) -
Hirano Shigeki,
Eckert Thomas,
Flanagan Toni,
Eidelberg David
Publication year - 2009
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22541
Subject(s) - parkinson's disease , deep brain stimulation , neuroimaging , progressive supranuclear palsy , subthalamic nucleus , neuroscience , movement disorders , atrophy , disease , cognition , dopaminergic , psychology , medicine , physical medicine and rehabilitation , pathology , dopamine
Abstract Neuroimaging and modern computational techniques like spatial covariance analysis have contributed greatly to the understanding of neural system abnormalities in neurodegenerative disorders such as Parkinson's disease (PD). The application of network analysis to metabolic PET data obtained from patients with PD has led to the identification and validation of two distinct spatial covariance patterns associated with the motor and cognitive manifestations of the disease. Quantifying the activity of these patterns in individual subjects has provided an objective tool for the assessment of treatment efficacy and differential diagnosis. We have found that activity of the PD motor‐related network is modulated by antiparkinsonian treatments such as dopaminergic therapy, deep brain stimulation (DBS), and subthalamic nucleus (STN) gene therapy. By contrast, the cognitive‐related network is not altered by these interventions for PD motor symptoms. This pattern may however change in response to therapies targeting the cognitive symptoms of this disorder. Recent work has focused on the identification of specific network biomarkers for atypical parkinsonian conditions such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). These disease‐related patterns can potentially be used in an automated imaging‐based algorithm to classify patients with these disorders. © 2009 Movement Disorder Society