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Impulsive and compulsive behaviors in Parkinson's disease
Author(s) -
Evans Andrew H.,
Strafella Antonio P.,
Weintraub Daniel,
Stacy Mark
Publication year - 2009
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22505
Subject(s) - hypersexuality , psychology , impulse control disorder , compulsive behavior , dopaminergic , dopamine , psychiatry , neuroscience , pathological , medicine , clinical psychology , sexual behavior , pathology
Antiparkinson therapy can be the primary cause of a range of nonmotor symptoms that include a set of complex disinhibitory psychomotor pathologies and are linked by their repetitive, reward or incentive‐based natures. These behaviors relate to aberrant or excessive dopamine receptor stimulation and encompass impulse control disorders (ICDs), punding, and the dopamine dysregulation syndrome (DDS). Common ICDs include pathological gambling, hypersexuality, compulsive eating, and compulsive buying. This review focuses on the phenomenology, epidemiology, and methods to identify and rate these disorders. The management of dopaminergic drug‐related compulsive behaviors is discussed in the light of the current understanding of the neurobiological substrate of these disorders. © 2009 Movement Disorder Society