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Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment
Author(s) -
Hosokai Yoshiyuki,
Nishio Yoshiyuki,
Hirayama Kazumi,
Takeda Atsushi,
Ishioka Toshiyuki,
Sawada Yoichi,
Suzuki Kyoko,
Itoyama Yasuto,
Takahashi Shoki,
Fukuda Hiroshi,
Mori Etsuro
Publication year - 2009
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22444
Subject(s) - parkinson's disease , cognitive impairment , disease , degenerative disease , medicine , carbohydrate metabolism , alzheimer's disease , cognition , neuroscience , central nervous system disease , psychology
There is no consensus with regard to the clinical and neuroimaging characteristics of prodromal dementia in Parkinson's disease (PD). To delineate functional neuroimaging features of PD with mild cognitive impairment (PDMCI) and with no cognitive impairment (PDNC), we compared regional cerebral glucose metabolism (CMRglc) amongst 13 patients with PDMCI, 27 with PDNC, and 13 healthy controls. The PDNC patients had limited areas of hypometabolism in the frontal and occipital cortices. In the PDMCI patients, there were extensive areas of hypometabolism in the posterior cortical regions, including the temporo‐parieto‐occipital junction, medial parietal, and inferior temporal cortices. The present results suggest that posterior cortical dysfunction is the primary neuroimaging feature of PD patients at risk for dementia. © 2009 Movement Disorder Society