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Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community
Author(s) -
Mehta Prachi,
Mellick George D.,
Rowe Dominic B.,
Halliday Glenda M.,
Jones Michael M.,
Manwaring Neil,
Vandebona Himesha,
Silburn Peter A.,
Wang Jie Jin,
Mitchell Paul,
Sue Carolyn M.
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22389
Subject(s) - haplogroup , mitochondrial dna , human mitochondrial dna haplogroup , disease , parkinson's disease , medicine , degenerative disease , neuroscience , genetics , biology , haplotype , pathology , gene , allele
MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population‐based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6–12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5–8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2–11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9–8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population‐based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD. © 2008 Movement Disorder Society