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LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han‐Chinese from mainland China
Author(s) -
Zhang Zijuan,
Burgunder JeanMarc,
An Xingkai,
Wu Yan,
Chen Wenjun,
Zhang Jinhong,
Wang Yingcheng,
Xu Yanming,
Gou Yingru,
Yuan Guanggu,
Mao Xueye,
Peng Rong
Publication year - 2009
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22371
Subject(s) - lrrk2 , odds ratio , medicine , risk factor , disease , parkinson's disease , cohort , mainland china , chinese people , population , gastroenterology , genetics , china , biology , environmental health , law , political science
Abstract Mutations in LRRK2 , the gene that encodes leucine‐rich repeat kinase 2 (LRRK2), are associated with autosomal dominant and sporadic forms of Parkinson's disease (PD) and are the most common genetic causes of PD. Recently, a R1628P variant has been reported as a risk factor for PD in Taiwan and Singapore. To determine the association of this variant and PD in the Han‐Chinese population from mainland China, we analyzed its frequency in a cohort of 600 patients and 459 unrelated healthy controls. Forty (6.7%) patients were heterozygous and 3 (0.5%) homozygous for the R1628P variant, which was significantly more frequent than in the controls [2.4% heterozygous and 0.0% homozygous, Odds ratio = 3.14, 95%CI: 1.60–6.17, P < 0.01]. Considering the age at onset, this difference was found only in late‐onset PD (older than 50) [Odds ratio = 3.76, 95% CI: 1.90–7.45, P < 0.01]. Our data confirms that the LRRK2 R1628P variant is associated with an increased risk to develop late onset PD in the ethnic Han‐Chinese population. © 2009 Movement Disorder Society