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Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
Author(s) -
Kordower Jeffrey H.,
Chu Yaping,
Hauser Robert A.,
Olanow C.Warren,
Freeman Thomas B.
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22369
Subject(s) - tyrosine hydroxylase , dopamine transporter , dopaminergic , parkinson's disease , thioflavin , pathology , dopamine , pathological , lewy body , neuroscience , transplantation , medicine , immunohistochemistry , disease , biology , alzheimer's disease
This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long‐term time point, some displayed Lewy bodies as evidenced by alpha‐synuclein, ubiquitin, and thioflavin‐S staining. Additionally, there was a general loss of dopamine transporter‐immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD‐like pathology is seen in young grafted neurons when they survive long term. © 2008 Movement Disorder Society