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Beta activity in the subthalamic nucleus during sleep in patients with Parkinson's disease
Author(s) -
Urrestarazu Elena,
Iriarte Jorge,
Alegre Manuel,
Clavero Pedro,
RodríguezOroz Mari Cruz,
Guridi Jorge,
Obeso José A.,
Artieda Julio
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22351
Subject(s) - subthalamic nucleus , deep brain stimulation , parkinson's disease , local field potential , wakefulness , dopaminergic , sleep (system call) , basal ganglia , neuroscience , psychology , beta rhythm , beta (programming language) , rapid eye movement sleep , sleep onset , medicine , slow wave sleep , dopamine , eye movement , electroencephalography , disease , central nervous system , insomnia , psychiatry , computer science , operating system , programming language
The recordings of local field potentials in the subthalamic nucleus in patients with Parkinson's disease (PD), carried out through the stimulators implanted to treat the motor symptoms of the disease, show a prominent basal (“off”) activity in the beta range, which is attenuated after dopaminergic therapy. A recent study described improvement of parkinsonian features during rapid eyes movements (REM) sleep. We describe, for the first time, the changes in activity of the subthlamic nucleus (STN) during different sleep stages in Parkinson's disease with special interest in the beta band. Ten patients with PD treated with deep brain stimulation of the STN were studied. Subthalamic local field potentials (LFPs) were recorded through the stimulation electrodes during wakefulness (“off” medication) and different sleep stages. In Stage 2 and slow‐wave sleep, a significant decrease of beta activity was recorded. During REM sleep, beta power values were similar to wakefulness values or even higher. These findings indicate that STN activity is modulated and modified during different sleep stages. The increased beta activity during REM sleep is a new but unexpected finding, which requires further analysis. © 2008 Movement Disorder Society