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Functional brain imaging in pure akinesia with gait freezing: [ 18 F] FDG PET and [ 18 F] FP‐CIT PET analyses
Author(s) -
Park Hee K.,
Kim Jae S.,
Im Ki C.,
Oh Seung J.,
Kim Mi J.,
Lee JaeHong,
Chung Sun J.,
Lee Myoung C.
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22347
Subject(s) - progressive supranuclear palsy , basal ganglia , dopaminergic , gait , parkinson's disease , positron emission tomography , nuclear medicine , pathophysiology , hypokinesia , movement disorders , medicine , psychology , pathology , atrophy , dopamine , central nervous system , disease , physical medicine and rehabilitation
Pure akinesia with gait freezing (PAGF) has characteristic features, including freezing of gait and prominent speech disturbance without rigidity or tremor. The purpose of this study was to investigate changes in brain glucose metabolism and presynaptic dopaminergic function in PAGF. By using [ 18 F] fluorodeoxyglucose (FDG) PET, 11 patients with PAGF were compared with 14 patients with probable progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD), and 11 normal controls. [ 18 F] N ‐(3‐fluoropropyl)‐2β‐carbon ethoxy‐3β‐(4‐iodophenyl) nortropane (FP‐CIT) PET was performed in 11 patients with PAGF and with 10 normal controls. The PAGF patients showed decreased glucose metabolism in the midbrain when compared with normal controls. PSP patients showed a similar topographic distribution of glucose hypometabolism with additional areas, including the frontal cortex, when compared with normal controls. The FP‐CIT PET findings in patients with PAGF revealed severely decreased uptake bilaterally in the basal ganglia. These findings suggest that both PAGF and PSP may be part of the same pathophysiologic spectrum of disease. However, the reason why PAGF manifests clinically in a different manner needs to be further elucidated. © 2008 Movement Disorder Society