MR‐spectroscopic findings in juvenile‐onset Huntington's disease | Zendy

Reynolds Norman C. | Zendy; Prost Robert W. | Zendy; Mark Leighton P. | Zendy; Joseph Suja A. | Zendy

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MR‐spectroscopic findings in juvenile‐onset Huntington's disease

Author(s) -

Reynolds Norman C.,

Prost Robert W.,

Mark Leighton P.,

Joseph Suja A.

Publication year - 2008

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.22245

Subject(s) - putamen , basal ganglia , abnormality , creatine , degenerative disease , juvenile , central nervous system disease , in vivo magnetic resonance spectroscopy , psychology , huntington's disease , medicine , pathology , disease , neuroscience , magnetic resonance imaging , biology , psychiatry , central nervous system , radiology , genetics

Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton‐MR‐spectroscopy ( 1 H‐MRS) profiles of the putamen. Despite clinical variability, the predominate 1 H‐MRS abnormality is elevated glutamate, expressed well beyond the confines of the basal ganglia, and low striatal creatine. © 2008 Movement Disorder Society

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