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MR‐spectroscopic findings in juvenile‐onset Huntington's disease
Author(s) -
Reynolds Norman C.,
Prost Robert W.,
Mark Leighton P.,
Joseph Suja A.
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22245
Subject(s) - putamen , basal ganglia , abnormality , creatine , degenerative disease , juvenile , central nervous system disease , in vivo magnetic resonance spectroscopy , psychology , huntington's disease , medicine , pathology , disease , neuroscience , magnetic resonance imaging , biology , psychiatry , central nervous system , radiology , genetics
Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton‐MR‐spectroscopy ( 1 H‐MRS) profiles of the putamen. Despite clinical variability, the predominate 1 H‐MRS abnormality is elevated glutamate, expressed well beyond the confines of the basal ganglia, and low striatal creatine. © 2008 Movement Disorder Society