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Urinary isoprostanes in Friedreich ataxia: Lack of correlation with disease features
Author(s) -
Myers Lauren M.,
Lynch David R.,
Farmer Jennifer M.,
Friedman Lisa S.,
Lawson John A.,
Wilson Robert B.
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22038
Subject(s) - urinary system , isoprostanes , ataxia , biomarker , oxidative stress , medicine , endocrinology , biology , lipid peroxidation , psychiatry , genetics
To assess the utility of urinary isoprostanes as markers of oxidative injury in Friedreich ataxia (FA), we compared levels of urinary F 2 ‐isoprostanes in patients with FA and healthy control subjects. Levels of urinary F 2 ‐isoprostanes in FA patients were not different from controls and were not significantly associated with age, GAA repeat length, disability level, or the use of antioxidants. Thus, urinary F 2 ‐isoprostanes are not a useful biomarker in FA. © 2008 Movement Disorder Society.