Urinary isoprostanes in Friedreich ataxia: Lack of correlation with disease features | Zendy

Myers Lauren M. | Zendy; Lynch David R. | Zendy; Farmer Jennifer M. | Zendy; Friedman Lisa S. | Zendy; Lawson John A. | Zendy; Wilson Robert B. | Zendy

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Urinary isoprostanes in Friedreich ataxia: Lack of correlation with disease features

Author(s) -

Myers Lauren M.,

Lynch David R.,

Farmer Jennifer M.,

Friedman Lisa S.,

Lawson John A.,

Wilson Robert B.

Publication year - 2008

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.22038

Subject(s) - urinary system , isoprostanes , ataxia , biomarker , oxidative stress , medicine , endocrinology , biology , lipid peroxidation , psychiatry , genetics

To assess the utility of urinary isoprostanes as markers of oxidative injury in Friedreich ataxia (FA), we compared levels of urinary F 2 ‐isoprostanes in patients with FA and healthy control subjects. Levels of urinary F 2 ‐isoprostanes in FA patients were not different from controls and were not significantly associated with age, GAA repeat length, disability level, or the use of antioxidants. Thus, urinary F 2 ‐isoprostanes are not a useful biomarker in FA. © 2008 Movement Disorder Society.

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