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Regression of symptoms after selective iron chelation therapy in a case of neurodegeneration with brain iron accumulation
Author(s) -
Forni Gian Luca,
Balocco Manuela,
Cremonesi Laura,
Abbruzzese Giovanni,
Parodi Roberto Carlo,
Marchese Roberta
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.22002
Subject(s) - chelation therapy , neurodegeneration , chelation , medicine , neuroscience , psychology , chemistry , disease , organic chemistry
We report the results of iron chelating treatment with deferiprone in a 61‐year‐old woman with signs and symptoms of neurodegeneration with brain iron accumulation (NBIA). After 6 months of therapy the patient's gait had improved and a reduction in the incidence of choreic dyskinesias was observed. Her gait returned to normal after an additional 2 months of therapy, at which time there was a further reduction in involuntary movements and a partial resolution of the blepharospasm. © 2008 Movement Disorder Society