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Assessment of idiopathic rapid‐eye‐movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP‐CIT‐SPECT
Author(s) -
Unger Marcus M.,
Möller Jens C.,
StiasnyKolster Karin,
Mankel Katharina,
Berg Daniela,
Walter Uwe,
Hoeffken Helmut,
Mayer Geert,
Oertel Wolfgang H.
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21908
Subject(s) - rem sleep behavior disorder , synucleinopathies , rapid eye movement sleep , psychology , physical medicine and rehabilitation , dementia with lewy bodies , neuroscience , pathological , parkinson's disease , neurological examination , hyposmia , medicine , eye movement , audiology , alpha synuclein , dementia , disease , pathology , covid-19 , infectious disease (medical specialty)
Idiopathic rapid‐eye‐movement (REM) sleep behavior disorder (iRBD) has been suggested to be a risk factor for subsequent development of neurodegenerative disorders, especially Parkinson's disease (PD) and other α‐synucleinopathies. At present, it is not possible to predict whether or not an iRBD patient will eventually develop PD. Here, we report 5 iRBD patients who underwent a test battery comprising a neurological examination (including UPDRS rating), mini mental state examination testing, transcranial sonography, olfactory function testing, and presynaptic dopamine transporter imaging with FP‐CIT‐SPECT. Our preliminary data show the diverse pattern of individual combinations of pathological findings when a multimodal assessment approach is applied in this patient group. Large‐size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD. © 2007 Movement Disorder Society