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Are parkin patients particularly suited for deep‐brain stimulation?
Author(s) -
Lohmann Ebba,
Welter MarieLaure,
Fraix Valérie,
Krack Paul,
Lesage Suzanne,
Laine Sophie,
Tanguy MarieLaure,
Houeto JeanLuc,
Mesnage Valérie,
Pollak Pierre,
Agid Yves,
Brice Alexis
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21903
Subject(s) - parkin , deep brain stimulation , levodopa , parkinson's disease , neurology , medicine , neurosurgery , central nervous system disease , disease , psychology , surgery , psychiatry
Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow‐up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results. © 2008 Movement Disorder Society