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Mood disorder following DBS of the left amygdaloid region in a dystonia patient with a dislodged electrode
Author(s) -
Piacentini Sylvie,
Romito Luigi,
Franzini Angelo,
Granato Alberto,
Broggi Giovanni,
Albanese Alberto
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21805
Subject(s) - dystonia , deep brain stimulation , amygdala , depression (economics) , medicine , stimulation , psychology , audiology , physical medicine and rehabilitation , anesthesia , neuroscience , psychiatry , parkinson's disease , disease , economics , macroeconomics
Continuous high‐frequency stimulation of the globus pallidum internum (GPi) is an accepted treatment for patients with primary dystonia. In a series of 18 consecutive dystonia cases that were successfully treated by bilateral GPi stimulation, 1 patient had an adverse event involving the downward migration of the electrodes. He developed remarkable behavioral complications and was found to have dislodgement of the left electrode to a position close to the left amygdala. The patient developed behavioral changes consisting of depression, psychotic symptoms, and heightened pain perception. This syndrome reverted when the left electrode was removed and a new one inserted in the correct position. We describe in detail the clinical features associated with left amygdala dysregulation induced by high‐frequency stimulation through the displaced electrode. © 2007 Movement Disorder Society