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Transcranial sonography findings in welding‐related Parkinsonism in comparison to Parkinson's disease
Author(s) -
Walter Uwe,
Dressler Dirk,
Lindemann Christian,
Slachevsky Andrea,
Miranda Marcelo
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21795
Subject(s) - parkinsonism , substantia nigra , parkinson's disease , echogenicity , medicine , levodopa , pathophysiology , central nervous system disease , psychology , disease , surgery , ultrasonography
The pathogenetic relationship of welding‐related Parkinsonism (WP) and idiopathic Parkinson's disease (PD) is a matter of debate. In the present study, we compared transcranial sonography (TCS) findings in patients with WP and PD. Two male patients with WP, who had developed levodopa‐resistant akinetic‐rigid Parkinsonism without ongoing progression after having worked as welders for many years in Chilean mines in confined spaces without adequate ventilation, and three age‐matched male patients with clinically definite akinetic‐rigid PD were studied with TCS in a random order by two investigators blind to clinical diagnoses. In both WP patients, normal echogenicity of substantia nigra was found whereas all PD patients exhibited marked substantia nigra hyperechogenicity, previously reported as a characteristic TCS finding in idiopathic PD. In contrast, lenticular nucleus was hyperechogenic in both WP patients but only in one of the PD patients. TCS findings suggest a different pathophysiology of Parkinsonism in WP and PD patients. © 2007 Movement Disorder Society