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Group I nonreciprocal inhibition in primary restless legs syndrome
Author(s) -
Scaglione Cesa,
Vetrugno Roberto,
Plazzi Giuseppe,
Rizzo Giovanni,
Provini Federica,
Montagna Pasquale,
Martinelli Paolo
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21794
Subject(s) - h reflex , neuroscience , interneuron , interstimulus interval , psychology , electrophysiology , reflex , restless legs syndrome , neurological disorder , latency (audio) , anesthesia , central nervous system disease , medicine , inhibitory postsynaptic potential , neurology , stimulation , electrical engineering , engineering
Electrophysiological investigations of restless legs syndrome (RLS) have found spinal circuits impinging on motoneurones. We evaluated the H reflex threshold, latency, the Hmax/Mmax ratio, and the short latency autogenic inhibition in 7 patients with RLS and 10 age‐matched controls by testing the excitability changes in soleus H reflex Ib interneuron function. A significant reduction in Ib inhibition at 4 ( P = 0.043), 5 ( P = 0.007), and 6 ms ( P = 0.001) of H reflex conditioning interstimulus interval was found in RLS patients. Data support the hypothesis that altered group I nonreciprocal inhibition is implicated in enhancing the spinal circuitry excitability of RLS, and are consistent with the view of an abnormal supraspinal drive to spinal interneurons in RLS. © 2007 Movement Disorder Society