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Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham‐controlled trial
Author(s) -
Mueller Joerg,
Skogseid Inger M.,
Benecke Reiner,
Kupsch Andreas,
Trottenberg Thomas,
Poewe Werner,
Schneider Gerd H.,
Eisner Wilhelm,
Wolters Alexander,
Müller J.U.,
Deuschl Günther,
Pinsker Marcus O.,
Roeste Geir K.,
VollmerHaase Juliane,
Brentrup Angela,
Krause Martin,
Tronnier Volker,
Schnitzler Alfons,
Voges Jüergen,
Nikkhah Guido,
Vesper Jan,
Naumann Markus,
Volkmann Jens
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21783
Subject(s) - deep brain stimulation , dystonia , neurostimulation , stimulation , quality of life (healthcare) , randomized controlled trial , medicine , physical medicine and rehabilitation , neurological disorder , psychology , anesthesia , physical therapy , central nervous system disease , neuroscience , parkinson's disease , disease , nursing
As part of the first randomized, sham‐timulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health‐related quality of life (HRQoL) was assessed by SF‐36. After the 3‐month sham‐controlled phase, significant HRQoL improvement occurred only in the active‐stimulation group. The open‐label extension phase resulted in a significant improvement in all SF‐36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia. © 2007 Movement Disorder Society