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Amantadine may reverse punding in Parkinson's disease—Observation in a patient
Author(s) -
Kashihara Kenichi,
Imamura Takaki
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21780
Subject(s) - amantadine , dopaminergic , levodopa , parkinson's disease , medicine , disease , psychology , psychiatry , pharmacology , dopamine
Punding, complex stereotyped behavior, sometimes occurs in patients with Parkinson's disease under dopaminergic replacement therapy. Reduction of dopaminergic drugs may reduce the problem but risks enhancing motor impairment. We report a patient with Parkinson's disease presenting disabling punding, which was reversed by amantadine without aggravating motor function. Amantadine may reduce punding by blocking NMDA receptors, in the same manner as in levodopa‐induced dyskinesias. © 2007 Movement Disorder Society