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Acute ataxia, Graves' disease, and stiff person syndrome
Author(s) -
Chia SuYnn,
Chua Richard,
Lo YewLong,
Wong MengCheong,
Chan LingLing,
Tan EngKing
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21703
Subject(s) - stiff person syndrome , medicine , ataxia , graves' disease , disease , pediatrics , thyroiditis , type 1 diabetes , autoimmune disease , neurological disorder , autoimmune thyroiditis , diabetes mellitus , central nervous system disease , surgery , endocrinology , psychiatry , biochemistry , chemistry , glutamate decarboxylase , enzyme
Stiff person syndrome (SPS) has been associated with autoimmune diseases, such as Type 1 diabetes mellitus and autoimmune thyroid disease (Hashimoto's thyroiditis), among others. The association of SPS with hyperthyroidism is extremely rare. We describe a patient with uncontrolled Graves' disease and undiagnosed SPS, who presented initially with acute ataxia simulating a cerebrovascular accident. Initiation of immunosuppressive therapy dramatically improved the patient's Graves' disease within 2 weeks but the neurological symptoms were not alleviated after a follow‐up period of 3 years. © 2007 Movement Disorder Society