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Myocardial 123 metaiodobenzylguanidine uptake in genetic Parkinson's disease
Author(s) -
Quattrone Aldo,
Bagnato Antonio,
Annesi Grazia,
Novellino Fabiana,
Morgante Letterio,
Savettieri Giovanni,
Zappia Mario,
Tarantino Patrizia,
Candiano Innocenza Claudia Cirò,
Annesi Ferdinanda,
Civitelli Donatella,
Rocca Francesca Emanuela,
D'Amelio Marco,
Nicoletti Giuseppe,
Morelli Maurizio,
Petrone Alfredo,
Loizzo Piercostanzo,
Condino Francesca
Publication year - 2008
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21701
Subject(s) - pink1 , lrrk2 , parkin , parkinson's disease , medicine , mutation , gene mutation , endocrinology , cardiology , disease , gene , gastroenterology , genetics , biology
Myocardial 123 Metaiodobenzylguanidine (MIBG) enables the assessment of postganglionic sympathetic cardiac innervation. MIBG uptake is decreased in nearly all patients with Parkinson's disease (PD). Our objective was to evaluate MIBG uptake in patients with genetic PD. We investigated MIBG uptake in 14 patients with PD associated with mutations in different genes ( Parkin , DJ‐1 , PINK1 , and leucine‐rich repeat kinase 2 ‐ LRRK2 ), in 15 patients with idiopathic PD, and 10 control subjects. The myocardial MIGB uptake was preserved in 3 of the 4 Parkin‐associated Parkinsonisms, in 1 of the 2 patients with DJ‐1 mutations, in 1 of the 2 brothers with PINK1 mutations, in 3 of the 6 unrelated patients with Gly2019Ser mutation in the LRRK2 gene, whereas it was impaired in all patients with idiopathic PD. MIBG was preserved in all control subjects. Our study shows that myocardial MIGB uptake was normal in 8 of 14 patients with genetic PD, suggesting that cardiac sympathetic denervation occurs less frequently in genetic PD than in idiopathic PD. Our findings also demonstrate that MIGB uptake has a heterogeneous pattern in genetic PD, because it was differently impaired in patients with different mutations in the same gene or with the same gene mutation. © 2007 Movement Disorder Society