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Subdural motor cortex stimulation in Parkinson's disease does not modify movement‐related rCBF pattern
Author(s) -
Strafella Antonio P.,
Lozano Andres M.,
Lang Anthony E.,
Ko Ji Hyun,
Poon YuYan,
Moro Elena
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21691
Subject(s) - deep brain stimulation , subthalamic nucleus , parkinson's disease , stimulation , neuroscience , motor cortex , cerebral blood flow , psychology , physical medicine and rehabilitation , medicine , movement disorders , supplementary motor area , anesthesia , disease , functional magnetic resonance imaging
There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [ 15 O] H 2 O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF‐condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement‐related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement‐related activation pattern in patients with advanced PD. © 2007 Movement Disorder Society