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Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome
Author(s) -
Wu Steve W.,
Graham Brent,
Gelfand Michael J.,
Gruppo Ralph E.,
Dinopolous Argirios,
Gilbert Donald L.
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21657
Subject(s) - chorea , positron emission tomography , medicine , antiphospholipid syndrome , putamen , movement disorders , anticardiolipin antibodies , antibody , pathology , nuclear medicine , immunology , disease
A fourteen‐year‐old right‐handed male with a history of attention deficit hyperactivity disorder (ADHD) presented with alternating hemichorea. Laboratory findings included elevated anticardiolipin IgG and anti‐β 2 ‐glycoprotein I IgG, which were consistent with primary antiphospholipid antibody syndrome. Positron emission tomography (PET) imaging revealed altered striatal metabolism in his left putamen while he was exhibiting right‐sided hemichorea. His symptoms resolved on prednisone; however, his antiphospholipid antibody profile remained markedly abnormal despite being symptom‐free for 26 months. © 2007 Movement Disorder Society