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Dopa‐responsive pseudo‐orthostatic tremor in parkinsonism
Author(s) -
Thomas Astrid,
Bonanni Laura,
Antonini Angelo,
Barone Paolo,
Onofrj Marco
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21621
Subject(s) - parkinsonism , levodopa , dopamine transporter , medicine , orthostatic vital signs , dopamine , essential tremor , physical medicine and rehabilitation , parkinson's disease , disease , dopaminergic , blood pressure
In four patients an inabilitating standing tremor appeared years before that parkinsonian symptoms were evidenced. This tremor was refractory to gabapentin and dramatically responded to Levodopa administration. Its dominant frequency was 6.2 to 6.9 Hz with sporadic subharmonics at 8 to 18 Hz. Three patients were affected by different genetic mutations (Park 2, Park 6, mtDNA deletion) in one no genetic or metabolic alterations could be evidenced. All patients had dopamine transporter abnormalities. We suggest that the term “Pseudo‐Orthostatic Tremor” could be used to define this Dopa responsive, 6 to 7 Hz standing tremor. © 2007 Movement Disorder Society