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Voxel based morphometry reveals specific gray matter changes in primary dystonia
Author(s) -
Egger Karl,
Mueller Joerg,
Schocke Michael,
Brenneis Christian,
Rinnerthaler Martina,
Seppi Klaus,
Trieb Thomas,
Wenning Gregor K.,
Hallett Mark,
Poewe Werner
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21619
Subject(s) - dystonia , cervical dystonia , voxel based morphometry , globus pallidus , psychology , voxel , medicine , neuroscience , anatomy , magnetic resonance imaging , basal ganglia , central nervous system , radiology , white matter
Abstract The present study assessed patterns of brain tissue alterations in different types of primary dystonia using voxel‐based morphometry (VBM). Nine patients with primary generalized dystonia (GD), 11 patients with primary cervical dystonia (CD), and 11 patients with primary focal hand dystonia (FHD) as well as 31 age and gender‐matched controls were included. When compared with healthy controls, patients with primary dystonia (n = 31) showed gray matter volume increase bilaterally in the globus pallidus internus, nucleus accumbens, prefrontal cortex, as well as unilaterally in the left inferior parietal lobe. This is the first study using VBM in patients with different types of primary dystonia, showing a common pattern of gray matter changes. © 2007 Movement Disorder Society