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Augmentation as a treatment complication of restless legs syndrome: Concept and management
Author(s) -
GarcíaBorreguero Diego,
Allen Richard P.,
Benes Heike,
Earley Christopher,
Happe Svenja,
Högl Birgit,
Kohnen Ralf,
Paulus Walter,
Rye David,
Winkelmann Juliane
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21610
Subject(s) - restless legs syndrome , complication , medicine , neurological disorder , movement disorders , trunk , physical medicine and rehabilitation , physical therapy , pediatrics , intensive care medicine , surgery , central nervous system disease , disease , psychiatry , neurology , ecology , biology
Augmentation constitutes the main complication of long‐term dopaminergic treatment in restless legs syndrome (RLS). Although this condition was first described in 1996, and is characterized by an overall increase in severity of RLS symptoms (including earlier onset of symptoms during the day, faster onset of symptoms when at rest, expansion to the upper limbs and trunk, and shorter duration of the treatment effect), precise diagnostic criteria were not established until 2003. These criteria have recently been updated to form a new definition of augmentation based on multicentric studies. The present article reviews our current knowledge on clinical diagnosis, evaluation, pathophysiology, and treatment recommendations for this condition. © 2007 Movement Disorder Society