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Levodopa responsiveness in disorders with parkinsonism: A review of the literature
Author(s) -
Constantinescu Radu,
Richard Irene,
Kurlan Roger
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21578
Subject(s) - progressive supranuclear palsy , parkinsonism , corticobasal degeneration , movement disorders , levodopa , dyskinesia , parkinson's disease , tolerability , atrophy , psychology , nosology , medicine , dystonia , disease , degenerative disease , confusion , psychiatry , pediatrics , physical medicine and rehabilitation , adverse effect , psychoanalysis
A literature review was conducted to investigate whether or not levodopa (LD) responsiveness (LR) is a useful criterion in the diagnosis of parkinsonian disorders. Although LR does appear to differ among the parkinsonian disorders, there is considerable confusion in the literature. While most patients with Parkinson's disease (PD) have a sustained benefit from LD, a small minority of patients with documented PD do not respond. The literature suggests that the LR rate is higher for multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) than based on published diagnostic criteria. Magnitude and duration of response to LD and tolerability (time course, type and distribution of dyskinesias, mental effects and motor worsening) may be useful features in distinguishing PD, MSA, PSP, and CBD. Efforts should be directed toward better defining LR when used for diagnostic purposes and in scientific publications. © 2007 Movement Disorder Society