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Skin cancers and precancerous lesions in Parkinson's disease patients
Author(s) -
Ferreira Joaquim,
Silva João Maia,
Freire Rita,
Pignatelli João,
Guedes Leonor Correia,
Feijó Alexandra,
Rosa Mário Miguel,
Coelho Miguel,
Costa João,
Noronha Ana,
Hewett Russell,
Gomes A. Marques,
de Castro J.L. Cirne,
Rascol Olivier,
Sampaio Cristina
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21575
Subject(s) - actinic keratosis , medicine , basal cell carcinoma , epidemiology , dermatology , skin cancer , parkinson's disease , disease , keratosis , population , case control study , gastroenterology , pathology , basal cell , cancer , environmental health
Our objective was to evaluate the frequency of neoplastic and preneoplastic skin lesions in Parkinson's disease (PD) patients when compared with an aged‐matched population. We performed a cross‐sectional survey in PD patients and in an age‐matched control group. Patients and controls were examined by a movement disorder specialist and a dermatologist. 150 PD patients and 146 controls were included. Thirty‐five PD patients (23.3%) presented skin lesions that could be classified as neoplastic or preneoplastic vs. 20 subjects in the control group (13.7%) (OR 95%, CI 1.92 [1.05, 3.51]). However, this difference lost statistical significance when adjusted for gender (recruitment of controls was matched just for age with an over representation of males in the PD group). Twenty‐nine PD patients (19%) presented actinic keratosis and basal cell carcinoma was diagnosed in 4 patients (3%). Although nonconclusive, our results are in agreement with previous studies suggesting an increased risk of skin cancer in PD patients. The frequency of actinic keratosis in PD patients and the associated risk to develop melanoma recommends its screening in future epidemiological studies. © 2007 Movement Disorder Society