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Reversible posterior leukoencephalopathy syndrome in a patient with multiple system atrophy: A possible association with oral midodrine treatment
Author(s) -
Kim JoongSeok,
Lee KwangSoo,
Lim SungChul,
Ahn JaeYoung,
Song InUk,
Kim YeongIn,
Kim BumSoo,
Kim HeeTae
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21461
Subject(s) - midodrine , medicine , supine position , atrophy , orthostatic vital signs , leukoencephalopathy , magnetic resonance imaging , pediatrics , anesthesia , radiology , blood pressure
We describe a 51‐year‐old man with a 3‐year history of multiple system atrophy, who developed a reversible posterior leukoencephalopathy syndrome (RPLS) after receiving prescription midodrine for therapeutic treatment of orthostatic hypotension. Typical reversible magnetic resonance imaging findings, following treatment with midodrine, suggested a possible relationship between midodrine treatment, supine hypertension, and RPLS, although a cause‐and‐effect relationship cannot be confirmed. © 2007 Movement Disorder Society