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Olfactory loss may be a first sign of idiopathic Parkinson's disease
Author(s) -
Haehner Antje,
Hummel Thomas,
Hummel Cornelia,
Sommer Ulrike,
Junghanns Susann,
Reichmann Heinz
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21413
Subject(s) - hyposmia , medicine , parkinson's disease , substantia nigra , parkinsonism , disease , anosmia , degenerative disease , audiology , pathology , psychology , covid-19 , infectious disease (medical specialty)
Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow‐up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and 123 I‐FP‐CIT SPECT imaging. At the present neurological examination, 7% of the individuals with idiopathic hyposmia had developed clinical IPD. Altogether, 13% presented with abnormalities of the motor system. Our data suggest that a combination of olfactory testing and other tests may constitute a screening tool for the risk to develop IPD. © 2007 Movement Disorder Society