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Cell type‐specific neuronal loss in the putamen of patients with multiple system atrophy
Author(s) -
Sato Kenta,
Kaji Ryuji,
Matsumoto Sadayuki,
Goto Satoshi
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21385
Subject(s) - putamen , neurodegeneration , choline acetyltransferase , atrophy , parkinsonism , neuroscience , biology , pathology , globus pallidus , medicine , central nervous system , basal ganglia , disease
Using antibodies to calcineurin (CaN) and choline acetyltransferase (ChAT), we performed topographical and cellular immunohistochemical analysis on the posterior putamen of autopsied patients with multiple system atrophy with predominant parkinsonism (MSA‐P). We document that in these patients, medium spiny neurons positive for CaN were severely depleted in the dorsolateral portion of the posterior putamen where ChAT‐positive neurons are normally distributed. Our findings indicate that in patients with MSA‐P, striatal neurons manifest a cell type‐specific vulnerability to neurodegeneration. © 2007 Movement Disorder Society