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GAD antibody positive paraneoplastic stiff person syndrome in a patient with renal cell carcinoma
Author(s) -
McHugh John C.,
Murray Brian,
Renganathan Radhakrishnan,
Connolly Sean,
Lynch Tim
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21374
Subject(s) - stiff person syndrome , autoantibody , renal cell carcinoma , medicine , amphiphysin , antibody , glutamate decarboxylase , occult , carcinoma , nephrectomy , pathogenesis , immunology , kidney , pathology , receptor , biology , biochemistry , endocytosis , alternative medicine , dynamin , enzyme
Abstract Stiff person syndrome (SPS) is an unusual cause of muscle rigidity and spasms. It is believed to have an autoimmune pathogenesis and is associated with autoantibodies to glutamic acid decarboxylase (GAD). Paraneoplastic SPS (PSPS) has been described mainly in relation to breast cancer and is associated with antibodies to amphiphysin. Few reports of PSPS document the finding of GAD autoantibodies. We present the first reported case of anti‐GAD positive PSPS in a 53‐year‐old male with occult renal carcinoma. Clinical benefit was marked following nephrectomy and intravenous immunoglobulin treatment. Renal carcinoma should be considered in patients with SPS. © 2007 Movement Disorder Society