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Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population
Author(s) -
López Marisol,
Guerrero Jorge,
Yescas Petra,
Boll MarieCatherine,
Familiar Itziar,
Ochoa Adriana,
Rasmussen Astrid,
Alonso María Elisa
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21340
Subject(s) - apolipoprotein e , allele , genotype , parkinson's disease , medicine , degenerative disease , genetics , disease , gastroenterology , biology , gene
We investigated the association between apolipoprotein E ( APOE ) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE ‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases ( P = 0.025). © 2006 Movement Disorder Society