Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population | Zendy

López Marisol | Zendy; Guerrero Jorge | Zendy; Yescas Petra | Zendy; Boll MarieCatherine | Zendy; Familiar Itziar | Zendy; Ochoa Adriana | Zendy; Rasmussen Astrid | Zendy; Alonso María Elisa | Zendy

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Apolipoprotein E ε4 allele is associated with Parkinson disease risk in a Mexican Mestizo population

Author(s) -

López Marisol,

Guerrero Jorge,

Yescas Petra,

Boll MarieCatherine,

Familiar Itziar,

Ochoa Adriana,

Rasmussen Astrid,

Alonso María Elisa

Publication year - 2007

Publication title -

movement disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.352

H-Index - 198

eISSN - 1531-8257

pISSN - 0885-3185

DOI - 10.1002/mds.21340

Subject(s) - apolipoprotein e , allele , genotype , parkinson's disease , medicine , degenerative disease , genetics , disease , gastroenterology , biology , gene

We investigated the association between apolipoprotein E ( APOE ) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE ‐ε4 allele and APOE ε4/ε3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases ( P = 0.025). © 2006 Movement Disorder Society

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