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ELAVL4, PARK10, and the Celts
Author(s) -
Haugarvoll Kristoffer,
Toft Mathias,
Ross Owen A.,
Stone Jeremy T.,
Heckman Michael G.,
White Linda R.,
Lynch Timothy,
Gibson John Mark,
Wszolek Zbigniew K.,
Uitti Ryan J.,
Aasly Jan O.,
Farrer Matthew J.
Publication year - 2007
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.21336
Subject(s) - norwegian , irish , degenerative disease , disease , medicine , philosophy , linguistics
Abstract Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age‐at‐onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case–control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic‐founder effect. © 2007 Movement Disorder Society